The Natanebi (Georgian: ნატანები) is a river in western Georgia, located in the region of Guria. It flows into the Black Sea near Shekvetili. It is 60 km (37 mi) long, and has a drainage basin of 657 km2 (254 sq mi).
The Natanebi corresponds to the ancient River Isis, described by Greek historian Arrian of Nicomedia in his Periplus of the Euxine Sea.
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